Abstract
We report the design and synthesis of equipotent PPARalpha/gamma dual agonists starting from selective PPAR alpha agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.
MeSH terms
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Animals
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Combinatorial Chemistry Techniques
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Drug Design
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Molecular Structure
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PPAR alpha / agonists*
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PPAR gamma / agonists*
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Protein Isoforms
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Pyrazoles / chemical synthesis*
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Pyrazoles / chemistry
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Pyrazoles / toxicity
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Rats
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Rats, Zucker
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Structure-Activity Relationship
Substances
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PPAR alpha
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PPAR gamma
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Protein Isoforms
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Pyrazoles